Endogenous Retroviruses in Trophoblast Differentiation and Placental Development
نویسندگان
چکیده
منابع مشابه
Endogenous retroviruses regulate periimplantation placental growth and differentiation.
Endogenous retroviruses (ERVs) are fixed and abundant in the genomes of vertebrates. Circumstantial evidence suggests that ERVs play a role in mammalian reproduction, particularly placental morphogenesis, because intact ERV envelope genes were found to be expressed in the syncytiotrophoblasts of human and mouse placenta and to elicit fusion of cells in vitro. We report here in vivo and in vitro...
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Endogenous retroviruses (ERVs) appear to have a particular predilection for placentas: retroviral genes have repeatedly been coopted for placental functions. In this issue, Chuong draws attention to the important contribution of retroviral promoters in rewiring placental development [1]. He proposes that trophoblast cells provide a permissive epigenetic environment for ERV activity because plac...
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Close to half of the human genome encompasses mobile genetic elements, most of which are retrotransposons. These genetic invaders are formidable evolutionary forces that have shaped the architecture of the genomes of higher organisms, with some conserving the ability to induce new integrants within their hosts' genome. Expectedly, the control of endogenous retroviruses is tight and multi-pronge...
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ژورنال
عنوان ژورنال: American Journal of Reproductive Immunology
سال: 2010
ISSN: 1046-7408
DOI: 10.1111/j.1600-0897.2010.00860.x